An evaluation of the ASPREE (ASPirin in Decreasing Occasions within the Aged) trial discovered that using low-dose aspirin was related to a 20 p.c elevated incidence of anemia and decline in ferritin, or blood iron ranges, in in any other case wholesome older adults. These findings counsel that periodic monitoring of hemoglobin needs to be thought of in older sufferers taking aspirin. The evaluation is revealed in Annals of Inside Medication.
Roughly half of older individuals in the US have reported preventative aspirin use. One of many problems of aspirin use is an elevated danger for main bleeding, notably gastrointestinal bleeding. Though the danger for overt bleeding on account of aspirin has been nicely characterised, only a few research have measured the impact of aspirin on anemia, notably in older populations.
Researchers from Monash College, Melbourne carried out a post-hoc evaluation of the ASPREE randomized managed trial. The trial included 19,114 individuals aged 70 years or older who had been randomly assigned to take 100 mg of aspirin each day or placebo. Hemoglobin was measured yearly, and ferritin was measured at baseline and three years after randomization.
The information confirmed that the danger for creating anemia was 23.5 p.c amongst these assigned to obtain low-dose aspirin. These outcomes had been accompanied by a small however better lower in imply hemoglobin and a better decline in ferritin concentrations amongst these receiving aspirin.
Variations in clinically important bleeding occasions didn’t account for the general distinction in incident anemia or the decline in ferritin noticed in ASPREE however was most certainly on account of occult blood loss given the noticed steeper decline in ferritin in contributors allotted to aspirin.
Extra data:
Impact of Low Dose Aspirin versus Placebo on Incidence of Anemia within the Aged, Annals of Inside Medication (2023). DOI: 10.7326/M23-0675
American Faculty of Physicians
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Low-dose aspirin use related to 20% elevated anemia danger in older adults (2023, June 19)
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