Within the central nervous system (CNS), a big group of glial
cells referred to as astrocytes play essential roles in each physiological and
illness situations. Astrocytes take part within the formation of
neurovascular items and work together carefully with different cells of the CNS,
equivalent to microglia and neurons. Stroke is a worldwide illness with excessive
mortality and incapacity price, most of that are ischemic stroke.
Important strides in understanding astrocytes have been revamped the
previous few a long time. Astrocytes reply strongly to ischemic stroke by
a course of generally known as activation or reactivity. Given the essential position
performed by reactive astrocytes (RAs) in several spatial and temporal
features of ischemic stroke, there’s a rising curiosity within the potential
therapeutic position of astrocytes. Presently, interventions concentrating on
astrocytes, equivalent to mediating astrocyte polarization, lowering edema,
regulating glial scar formation, and reprogramming astrocytes, have been
confirmed in modulating the development of ischemic stroke. The
aforementioned potential interventions on astrocytes and the crosstalk
between astrocytes and different cells of the CNS can be summarized on this
overview.