Sufferers with hemophilia A or B with inhibitors have a decrease annualized bleeding fee with concizumab than with no prophylaxis, in keeping with a section 3 examine revealed on-line Aug. 31 within the New England Journal of Drugs.
Tadashi Matsushita, M.D., Ph.D., from Nagoya College Hospital in Japan, and colleagues evaluated the protection and efficacy of concizumab in sufferers with hemophilia A or B with inhibitors. As a part of the explorer7 section 3 trial, individuals have been randomly assigned to obtain no prophylaxis for a minimum of 24 weeks (group 1; 19 sufferers) or to obtain concizumab prophylaxis for a minimum of 32 weeks (group 2; 33 sufferers), or they have been nonrandomly assigned to obtain concizumab prophylaxis for a minimum of 24 weeks (teams 3 and 4; 81 sufferers).
The researchers discovered that the estimated imply annualized bleeding fee in group 1 was 11.8 episodes versus 1.7 episodes in group 2 (fee ratio, 0.14; P “Concizumab represents a novel, subcutaneous therapy possibility in sufferers with hemophilia A or B with inhibitors that may probably enhance long-term outcomes,” the authors write.
Extra info:
Tadashi Matsushita et al, Section 3 Trial of Concizumab in Hemophilia with Inhibitors, New England Journal of Drugs (2023). DOI: 10.1056/NEJMoa2216455
H. Marijke van den Berg et al, Hemostasis—A Balancing Act, New England Journal of Drugs (2023). DOI: 10.1056/NEJMe2304535
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Concizumab could also be efficient prophylaxis for hemophilia A or B with inhibitors (2023, September 3)
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