Background
Present tips for the prevention and administration of cardiovascular ailments (CVD) present related suggestions for the usage of statins in each men and women. On this examine, we assessed intercourse variations within the depth of statin prescriptions at initiation and within the achievement of therapy targets, amongst people with out and with CVD, in a major care setting.
Strategies
Digital well being file knowledge from statin customers had been extracted from the PHARMO Knowledge Community. Poisson regressions had been used to analyze intercourse variations in statin depth and within the achievement of therapy targets. Analyses had been stratified by age group, illness standing and/or CVD danger class.
Outcomes
We included 82 714 people (46% ladies) aged 40–99 years outdated. In each sexes, the proportion of people with a disbursed prescription for high-intensity statin at initiation elevated between 2011 and 2020. Girls had been much less more likely to be prescribed high-intensity statins as in contrast with males, each within the subgroups with no historical past of CVD (danger ratio (RR) 0.69 (95% CI: 0.63 to 0.75)) and with CVD (RR 0.77 (95% CI: 0.74 to 0.81)). Girls had been much less possible than males to attain goal ranges of low-density lipoprotein ldl cholesterol following statin initiation within the subgroup with out CVD (RR 0.98 (95% CI: 0.97 to 1.00)) and with a historical past of CVD (RR 0.94 (95% CI: 0.89 to 0.98)).
Conclusion
In contrast with males, ladies had been much less more likely to be prescribed high-intensity statins at initiation and to attain therapy targets, each in individuals with out and with a historical past of CVD, and unbiased of variations in different particular person and scientific traits.