A cross-institutional analysis crew led by the LKS College of Medication, the College of Hong Kong (HKUMed), has developed a novel cinnamaldehyde-based prodrug nanomedicine by using cinnamaldehyde, a standard meals additive, as an anti-inflammatory agent.
The prodrug types nanoparticles that ship the therapeutic brokers exactly to the infected websites, providing an answer for the remedy of inflammatory ailments like rheumatoid arthritis (RA). This modern invention was awarded the “Gold Medal” on the Worldwide Exhibition of Innovations of Geneva.
The analysis findings had been revealed in Superior Healthcare Supplies and a patent utility was filed primarily based on this work.
Irritation is a organic self-response mechanism to guard the human physique from harm and an infection attributable to dangerous stimuli. Usually, an inflammatory response can help the physique in self-defense and restore. Nevertheless, dysregulated inflammatory responses could consequence within the improvement of assorted inflammatory ailments, comparable to RA and inflammatory bowel illness.
The first trigger of those situations entails the loosening of endothelial junctions, which permits inflammatory cell recruitment and infiltration into infected tissue. Subsequently, activated inflammatory cells promote the overproduction of assorted pro-inflammatory cytokines, that are chargeable for the initiation and development of inflammatory lesions.
Subsequently, the suppression of extreme pro-inflammatory cytokines is important for the prevention, alleviation, and remedy of assorted inflammatory ailments.
RA is a standard persistent inflammatory dysfunction attributable to a dysregulated immune response, which impacts 0.5–1% of the world’s inhabitants. Based on Hong Kong Arthritis & Rheumatism Basis Restricted, RA is a prevalent rheumatological illness in Hong Kong, and RA sufferers generally expertise numerous joint pains, steady bone erosion and deformity all through their our bodies.
Because the illness progresses, the deterioration of the joints considerably impairs their skill to operate, inflicting irreversible harm to their well being and high quality of life.
The present remedy methods for inflammatory ailments contain primarily the usage of anti-inflammatory drugs, together with non-steroidal anti-inflammatory medication, steroids, and organic brokers.
In extreme instances, surgical intervention could also be required as an adjunct remedy. Regardless of exceptional advances in anti-inflammation and aid of scientific signs, the present remedy strategy has been restricted by inadequate therapeutic efficacy and unfavorable systemic hostile results because of the lack of concentrating on skill, poor stability, and low water solubility. Subsequently, treating inflammatory ailments stays a major problem.
The analysis crew has developed a brand new prodrug nanosystem utilizing the FDA-approved meals additive cinnamaldehyde to deal with inflammatory ailments. By chemical modification, the analysis crew remodeled cinnamaldehyde right into a reactive oxygen species-responsive polymeric prodrug that may self-assemble into nanoparticles.
In experiments on two mouse fashions with RA and ulcerative colitis, the researchers discovered that these nanoparticles successfully accrued at infected websites of the mice by intravenous injection.
The accrued nanoparticles launched cinnamaldehyde in response to excessive concentrations of reactive oxygen species on the infected websites, which alleviated the development of irritation by inhibiting the overproduction of pro-inflammatory cytokines.
The outcomes from the mouse mannequin research demonstrated that the cinnamaldehyde prodrug nanomedicine could be exactly delivered to the infected websites, unleashing its therapeutic results with out inflicting harm to different regular tissues.
Professor Wang Weiping, affiliate professor of Dr. Li Dak-Sum Analysis Middle and Division of Pharmacology and Pharmacy, HKUMed, and the analysis member of the State Key Laboratory of Pharmaceutical Biotechnology, HKU, who led the analysis venture, identified that this expertise has three main advantages.
“First, the crew remodeled cinnamaldehyde right into a prodrug kind by chemical modification, which may successfully enhance the solubility and stability of the drug, making it simpler for the physique to soak up and keep its exercise,” he defined.
“Second, administering the drug in a nanoparticle kind will increase the buildup of the drug on the website of irritation, avoiding speedy metabolism of the drug and enhancing its therapeutic efficacy.
“Third, reactive oxygen species on the infected website can activate the drug to exert its results within the affected space. The cinnamaldehyde prodrug has a greater therapeutic efficacy than conventional medication, offering a groundbreaking strategy for focused drug supply within the remedy of inflammatory ailments.”
Professor Wang and his crew are at the moment engaged on growing an oral dosage type of cinnamaldehyde prodrugs, to assist sufferers simply adjust to their physician’s directions for medicine and promote future scientific translation.
Extra data:
Yaming Zhang et al, Reactive Oxygen Species‐Responsive Polymeric Prodrug Nanoparticles for Selective and Efficient Remedy of Inflammatory Illnesses, Superior Healthcare Supplies (2023). DOI: 10.1002/adhm.202301394
The College of Hong Kong
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